Molecular Characterization of the Na+/H+-Antiporter NhaA from Salmonella Typhimurium
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چکیده
منابع مشابه
Molecular Characterization of the Na+/H+-Antiporter NhaA from Salmonella Typhimurium
Na+/H+ antiporters are integral membrane proteins that are present in almost every cell and in every kingdom of life. They are essential for the regulation of intracellular pH-value, Na+-concentration and cell volume. These secondary active transporters exchange sodium ions against protons via an alternating access mechanism, which is not understood in full detail. Na+/H+ antiporters show disti...
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a Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, TelAviv University, Ramat Aviv 69978, Israel; b Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904 Jerusalem, Israel; c Department of Chemical Engineering, Polymer Research Center, Life Sciences and Technologies Research Center, Boğa...
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gradient for activation, both the wt and the pH-shifted G338S variant exhibit highly symmetrical transport activity with bell shaped pH dependencies, but the optimal pH was shifted 1.8 pH units to the acidic range in the variant. In both strains the pH dependence was associated with a systematic increase of the Km for Na + at acidic pH. Under symmetrical Na + concentration with a pH gradient fo...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0101575